Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	301 women with cyclical breast pain for >6 months	Adverse effects 80/155 (52%) with 10 mg daily doses of tamoxifen from days 15–25 in the menstrual cycle for 3 months 94/142 (66%) with 20 mg daily doses of tamoxifen from days 15–25 in the menstrual cycle for 3 months	P = 0.01	Effect size not calculated	10 mg daily doses of tamoxifen
RCT	301 women with cyclical breast pain for >6 months	Hot flushes 33/155 (21%) with 10 mg daily doses of tamoxifen from days 15–25 in the menstrual cycle for 3 months 54/142 (38%) with 20 mg daily doses of tamoxifen from days 15–25 in the menstrual cycle for 3 months	P = 0.015	Effect size not calculated	10 mg daily doses of tamoxifen
RCT	301 women with cyclical breast pain for >6 months	GI disturbances 30/155 (19%) with 10 mg daily doses of tamoxifen from days 15–25 in the menstrual cycle for 3 months 48/142 (34%) with 20 mg daily doses of tamoxifen from days 15–25 in the menstrual cycle for 3 months	P = 0.004	Effect size not calculated	10 mg daily doses of tamoxifen
RCT	60 women with cyclical and non-cyclical mastalgia	Adverse effects with tamoxifen 10 mg daily with tamoxifen 20 mg daily