Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Breast pain
RCT Crossover design	26 women with cyclical breast pain of at least 6 months' duration who had persistent symptoms after a 2-month observation period with no hormonal treatment	Pain scores with oral medroxyprogesterone acetate tablets with placebo Absolute results reported graphically	Reported as not significant The overall withdrawal rate was 15%		Not significant
RCT Crossover design	32 women with breast pain of at least 2 months' duration who were able to keep an updated diary with VAS of pain for 1 month	Pain scores measured by VAS before crossover with progesterone 1% cream with placebo cream Absolute results not reported	Reported as not significant Insufficient details were provided about the analysis 7/32 (22%) women withdrew from the study		Not significant