Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Breast pain
RCT 3-armed trial	93 women with severe cyclical mastalgia	Proportion of women with 50% pain relief at the end of 6 months' treatment 21/32 (66%) with danazol 200 mg daily over 6 months 23/32 (72%) with tamoxifen 10 mg daily over 6 months	P <0.001	Effect size not calculated	tamoxifen
RCT 3-armed trial	93 women with severe cyclical mastalgia	Proportion of women with 50% pain relief 12 months after the 6 months of treatment 12/32 (37%) with danazol 200 mg daily over 6 months 17/32 (53%) with tamoxifen 10 mg daily over 6 months	P <0.001	Effect size not calculated	tamoxifen