Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Breast pain
RCT	60 women with cyclical breast pain Subgroup analysis	Reduction in cyclical pain measured on visual analogue scale (VAS) from 0 = no pain to 10 = intolerable pain 6 months 5.87 with topical diclofenac 1.30 with placebo	P = 0.0001	Effect size not calculated	topical diclofenac
RCT	60 women with cyclical breast pain Subgroup analysis	Reduction in non-cyclical pain measured on VAS from 0 = no pain to 10 = intolerable pain 6 months 6.33 with topical diclofenac 1.12 with placebo	P = 0.0001	Effect size not calculated	topical diclofenac
RCT	60 women with cyclical breast pain Subgroup analysis	Proportion of women with no cyclical pain 6 months 14/30 (47%) with topical diclofenac 0/30 (0%) with placebo	P = 0.0001	Effect size not calculated	topical diclofenac
RCT	60 women with cyclical breast pain Subgroup analysis	Proportion of women with no non-cyclical pain 6 months 12/24 (50%) with topical diclofenac 0/24 (0%) with placebo	P = 0.0001	Effect size not calculated	topical diclofenac