Figure 2.

Ultrastructural nerve pathology (transmission electron microscopy, × 5 000) in CMT1A and HNPP.
(A) CMT1A: Superficial peroneal nerve pathology indicated by irregular thickening of the myelin sheath of myelinated nerve fibers, onion-like structures (→), and enlarged gaps in the myelin sheath surrounding the axons (↓).
(B) HNPP: Superficial peroneal nerve pathology indicated by a degenerated myelin sheath of myelinated nerve fibers, irregular thickening, loosing, edema, and a ‘mouse-nibbled’ appearance (←).
CMT1: Charcot-Marie-Tooth disease myelin sheath type; HNPP: hereditary neuropathy with liability to pressure palsies.