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. 2012 Dec 5;7(34):2663–2672. doi: 10.3969/j.issn.1673-5374.2012.34.003

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Neural differentiation of umbilical cord-derived mesenchymal stem cells (UC-MSCs; scale bars: 100 μm).

(A) Morphological changes in MSCs following neural differentiation. Cells before induction were recorded as day 0. Cultures of untreated MSCs display a characteristic fibroblastic morphology. Neurally induced MSCs underwent morphological changes and acquired a pseudo-neuronal shape with neurite-like processes, whereas MSCs in the control group maintained their flattened morphology.

(B) Immunocytochemical analysis of neural marker expression by MSCs after neural differentiation. After 7 days of induction, cells expressed neurofilament 200 (NF200), neuron-specific enolase (NSE), microtubule-associated protein 2 (MAP-2) and Tuj1, while the untreated control group did not express these markers. Nestin expression was significantly reduced in the neural induction group. Arrows indicate positive expression.