Figure 3.

Injection of ST104P suppressed tumor growth and prolonged the survival of Lewis lung carcinoma in mice. (A) The subcutaneous dorsa of mice were implanted with Lewis lung carcinomas. The tumor sizes in mice during treatment with ST104P or control were recorded. Treatment was performed by intratumor injection of ST104P (100 µg in 0.1 mL PBS) daily from day 0 to day 10 as indicated by the horizontal bar. Data were mean ± SEM for ten mice. Asterisks indicate statistical significance versus control. * p ˂ 0.05 and ** p ˂ 0.01; and (B) The overall survival rates of PBS- or ST104P-treated mice (n = 10). Kaplan-Meier survival analysis indicated the ST104P treatment significantly enhanced the survival rates of tumor-bearing mice (p < 0.001). This experiment was repeated with comparable results.