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. 2014 Aug 27;15(9):15090–15108. doi: 10.3390/ijms150915090

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Relative ease of forming 92-bp DNA loops anchored by various Lac repressor-bound O₃···O₁ and O_sym···O_sym operator models compared to loops terminated by identical rigid, O_sym operators. (a) Cartoon images illustrating the variability in the three operator structures. All views looking down the long axis of the kinked CG·CG step (blue) at the centerof the DNA fragments; (b) Distribution of the looping propensities, expressed in terms of the logarithmic values of the J factors, for the two classes of flexible anchoring conditions and for the rigid operator pair (). Note the enhancement in looping with the natural operators.

Inline graphic — Relative ease of forming 92-bp DNA loops anchored by various Lac repressor-bound O₃···O₁ and O_sym···O_sym operator models compared to loops terminated by identical rigid, O_sym operators. (a) Cartoon images illustrating the variability in the three operator structures. All views looking down the long axis of the kinked CG·CG step (blue) at the centerof the DNA fragments; (b) Distribution of the looping propensities, expressed in terms of the logarithmic values of the J factors, for the two classes of flexible anchoring conditions and for the rigid operator pair (). Note the enhancement in looping with the natural operators.