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. 2014 Aug 27;15(9):15073–15089. doi: 10.3390/ijms150915073

Figure 2.

Figure 2

Effects of Hericium erinaceus mycelium on infarcted volume in ischemic rats. The stroke animal model (SAM rat 1.5 h and reperfusion 24 h) was applied to rats as described in Experimental Section 4.2. H. erinaceus and erinacine A were administered intraperitoneally 90 min after the initial ischemia. The control group and SAM group animals received an equal volume of solvent. (A) Representative ischemic lesions at 2 mm thick coronal section from H. erinaceus at the dose of 50 and 300 mg/kg and erinacine A at the dose of 1 and 5 mg/kg (injection at 90 min in pre-stroke rats) as well as DMSO-treated rats at 1 day 2,3,5-triphenyl tetrazolium chloride (TTC) staining before ischemia; (B) Quantitative analysis of total infarcted volume to determine the therapeutic dose in groups of six rats treated with DMSO (control) or H. erinaceus and erinacine A at 24 h in pre-stroke rats. Cortex, subcortex, and total infarcted volumes were determined in the transient stroke rats (shown as percentage of the hemisphere). Data are expressed as mean ± SD of independent experiments. n = 6. * p < 0.05, SAM group versus SAM + H. erinaceus group. # p < 0.05, SAM group versus SAM + erinacine A group.