Table 1.
Potential targets of miRNA associated with cardiovascular biology.
| miRNA | Targets | References |
|---|---|---|
| Cardiac Development | ||
| miRNA-1–2 | Irx4, Hrt2, Hand1 and Gata6 | [120] |
| miRNA-1 | MyoD, Hand2 | [41,42] |
| miRNA-133 | Mef2 | [41,42] |
| miRNA-133a | SRF and cyclin D2 | [43] |
| miRNA-17–92 | STAT3 | [44,121] |
| miRNA-20 | Egln3 | [122] |
| miRNA-23b | Rb phosphorylation | [123] |
| miRNA-24 | BIM and GATA | [94] |
| miRNA-30c | CTGF | [79] |
| miRNA-143 | Adducin3 | [124] |
| Cardiac Hypertrophy | ||
| miRNA-150 | ACVR2A, c-myb | [125] |
| miRNA-208 | THRAP1, Myostatin | [56] |
| miRNA-23a | MuRF1 | [126] |
| miRNA-24 | NLK | [127] |
| miRNA-21 | SPRY2 | [128] |
| miRNA-195 | MO25 | [63] |
| miRNA-199 | Dyrk1a, Hif-1a, Sirt1 | [129,130,131,132] |
| miRNA-1 | RASGAP, MEF2A, GATA4 | [60,133] |
| miRNA-26b | GSK3β | [134] |
| miRNA-27a | TGF-β1 | [135] |
| miRNA-143 | ACE2 | [136] |
| miRNA-29 | TGFB3 | [127] |
| miRNA-133 | Nelf-A/WHSC2, Rho | [137] |
| Cardiac Fibrosis | ||
| miRNA-21 | Spry1, PTEN | [77] |
| miRNA-133 | CTGF | [79] |
| miRNA-29 | COL4A5 | [16] |
| Cardiac Arrhythmia | ||
| miRNA-1 | KCNJ2 GJA1 | [75] |
| miRNA-133 | KCNQ1 and SRF | [138] |
| miRNA-133a | Cx43 | [82] |
| miRNA-212 | Kir2.1 | [83,84] |
| miRNA-17–92 | Pitx2 | [87] |
| miRNA-106b | Pitx2 | [87] |
| miRNA-150 | AT1R | [88] |
| Cardiac Regeneration | ||
| miRNA-15a | Chek1 | [102] |
| miRNA-17–92 | PTEN | [103] |
| miRNA-195 | Chek1 | [102] |
| miRNA-133 | mps1, cdc37, PA2G4, cx43, cldn5 | [139] |
| miRNA-208 | βMHC | [41] |
| miRNA-499 | Sox6 and Rod1 | [115] |
| miRNA-24 | eNOS | [94] |
| Stem/Progenitor Cells Differentiation | ||
| miRNA-21 | SPRY2 | [110] |
| miRNA-221 | Bim | [140] |
| miRNA-34a | Sirt1 | [112] |
| miRNA-126 | Spred1 | [109,141] |