Table 1.
Patient characteristics according to GPER immunoreactivity as analyzed by the IR-score. Patient characteristics subdivided by diagnosis and by GPER immunoreactivity as quantified by immunoreactive score (IRS) are displayed. Lymph node status (pN) was only available in few cases (n (initial diagnosis) = 4, n (recurrence) = 5), because no lymph node dissection was performed or because information was missing. Data were tested for independence by applying Fisher’s exact test, and p-values below 0.05 were considered statistically significant. IRS = immuno-reactive score ranging from zero (no immunoreactivity) to 12 (high immunoreactivity); na = not applicable; ns = not significant.
| Initial Diagnosis (n = 15) | Recurrence (n = 11) | |||||
|---|---|---|---|---|---|---|
| GPER Negative (IRS ≤ 2; n = 7) | GPER Positive (IRS > 2; n = 8) | p | GPER Negative (IRS ≤ 2; n = 5) | GPER Positive (IRS > 2; n = 6) | p | |
| pT | ||||||
| pT1 | 5 | 6 | ns | 1 | 3 | ns |
| pT2, pT3 | 2 | 1 | 4 | 1 | ||
| pN | ||||||
| pN0 | 1 | 3 | na | 0 | 0 | na |
| pN1 | 0 | 0 | 4 | 1 | ||
| subcellular localization | ||||||
| cytoplasm | na | 3 | na | na | 3 | na |
| membr. + cytopl. | na | 4 | na | 2 | ||
| nucleus | na | 1 | na | 1 | ||
| distribution | ||||||
| focal | na | 7 | na | na | 4 | na |
| uniform | na | 1 | na | 2 | ||
| patient age | ||||||
| ≤54.8 years | 3 | 2 | ns | 4 | 2 | ns |
| >54.8 years | 4 | 6 | 1 | 4 | ||