Figure 1.

Schematic representation of truncated hRyR2 constructs. Putative TM regions (white bars) in RyR2^4TM and RyR2^10TM were reported previously (Takeshima et al., 1989; Zorzato et al., 1990). These constructs may also encode six TM-spanning regions (Du et al., 2002; see MATERIALS AND METHODS). Domains A, B, and C represent putative functional regions within RyR2 predicted from primary sequence analysis and from data obtained elsewhere (Chen et al., 1998; Du and MacLennan, 1999; Porter Moore et al., 1999; Du et al., 2000; Sun et al., 2001). Dotted and striped bars represent eGFP and dsRed, respectively.