Table 1.
Transcripts elevated (≥1.5-fold) in normal lung fibroblasts by a 4-h treatment with 100 nM ET-1
| Affymetrix ID | GenBank ID | Transcript name | Fold inductiona |
|---|---|---|---|
| Muscle actin | |||
| 200974_at | NM_001613.1 | Actin, alpha 2, smooth muscle, aorta | 1.5 |
| 202274_at | NM_001615.2 | Actin, gamma 2, smooth muscle, enteric | 1.9 |
| 201950_x_at | NM_004930.1 | Capping protein (actin filament) beta | 1.6 |
| 200720_s_at | NM_005736 | Actin-related protein 1, centractin alpha | 1.7 |
| 200729_s_at | NM_005722 | Actin-related protein 2 homolog | 2.6 |
| 200996_at | NM_005721 | Actin-related protein 3 homolog | 1.7 |
| 211672_s_at | NM_005718 | Actin-related protein 2/3 complex, subunit 4 | 2.0 |
| Proteins promoting actin-mediated contraction | |||
| 208613_s_at | AV712733 | Filamin B, beta (actin-binding protein-278) | 2.1 |
| 207876_s_at | NM_001458.1 | Filamin C, gamma (actin-binding protein-280) | 1.5 |
| 214040_s_at | BE675337 | Gelsolin | 2.5 |
| 218864_at | AF116610.1 | Tensin | 3.7 |
| 210978_s_at | BC002616.1 | Transgelin 2 | 2.5 |
| 214726_x_at | AL556041 | Adducin 1 (alpha) | 1.6 |
| 201616_s_at | M64110.1 | Caldesmon 1 | 3.7 |
| 206116_s_at | NM_000366.1 | Tropomyosin 1 (alpha) | 3.5 |
| 212481_s_at | AI214061 | Tropomyosin 4 | 3.7 |
| 212365_at | BF215996 | Myosin IB | 2.0 |
| Actin/cell membrane cross-linking proteins | |||
| 217234_s_at | AA670344 | Villin 2 (ezrin) | 4.0 |
| 200600_at | NM_002444.1 | Moesin (MSN) | 1.5 |
| 212398_at | AI057093 | Radixin | 4.0 |
a
Transcripts were identified as changed by the Affymetrix change algorythm (p < 0.001)