Table 2. Peripheral Quantitative Computerized Tomography of Femur.

Metaphysis (M) and diaphysis (D) regions from 14-week-old C57BL/6J Cftr-/- mice were compared to C57BL/6J mice via peripheral quantitative computerized tomography (pQCT at 2.5 mm and 7.5 mm proximal to the distal end of the femur respectively). Bone mineral content and density were decreased in male and female C57BL/6J Cftr-/- mice at both the metaphysis and diaphysis.

Measurement	Female C57BL/6J (n = 9)	Female C57BL/6J Cftr-/- (n = 5)	Male C57BL/6J (n = 5)	Male C57BL/6J Cftr-/- (n = 5)
M Total Content (mg/mm)	1.24±0.08	0.85±0.06 ‡	1.45±0.1	1.07±0.11 †
M Total Density (mg/cm3)	443.6±25.2	369.9±23.1 †	471.2±16.8	420.5±25.8 **
M Trabecular Content (mg/mm)	0.05±0.01	0.02±0.01 †	0.13±0.02	0.07±0.04 **
M Trabecular Density (mg/cm3)	60.8±12.5	35.5±5.8 **	144.8±14.5	89.6±45.8 *
M Cortical Content (mg/mm)	1.03±0.06	0.71±0.03 ‡	1±0.07	0.80±0.06 **
M Cortical Density (mg/cm3)	902.4±274	805.5±22.5 ‡	857.1±20	814.1±34.8 *
D Total Content (mg/mm)	1.01±0.05	0.79±0.06 ‡	1.17±0.07	0.87±0.08 †
D Total Density (mg/cm3)	642.1±17.3	604.1±45.9 *	660.2±19.5	599.1±3.2 †
D Cortical Content (mg/mm)	1.01±0.04	0.79±0.06 ‡	1.17±0.07	0.87±0.73 †
D Cortical Density (mg/cm3)	1075±21.4	1018±18.1 †	1097±11	1024±134 ‡
D Cortical Thickness (mm)	0.26±0.006	0.24±0.015 †	0.276±0.01	0.243±0.012 **
D Periosteal Circumference (mm)	443±0.14	4.05±0.17 †	4.72±0.12	4.26±0.21 **

M=Metaphysis, D=Diaphysis, p values for comparison to same-sex C57BL/6J mice:

^*p<0.05,

^**p<0.01,

^†p<0.001, and

^‡p<0.0001.