Table 1. Association of known T2D and obesity risk alleles with breast cancer risk by race/ethnicity.
| OR(95%CI)a Risk allele frequency in controls |
|||||||||
|---|---|---|---|---|---|---|---|---|---|
| SNP/ Allele testedb |
Chr./ Nearest gene |
European Americans 503 cases 633 controls |
African Americans 381 cases 542 controls |
Native Hawaiians 135 cases 344 controls |
Japanese Americans 509 cases 782 controls |
Latinos 355 cases 505 controls |
Pooled 1,883 cases 2,806 controls |
P for trend pooled |
Phetc |
| Type 2 Diabetes SNPs | |||||||||
| rs10923931 T |
1 NOTCH2 |
1.13(0.85-1.49) 0.097 |
0.87(0.71-1.07) 0.33 |
0.96(0.49-1.86) 0.055 |
0.97(0.58-1.63) 0.025 |
1.28(0.93-1.76) 0.095 |
1.01(0.88-1.15) 0.12 |
0.94 | 0.32 |
| rs7578597 T |
2 THADA |
1.05(0.88-1.48) 0.89 |
1.13(0.90-1.41) 0.75 |
1.04(0.54-2.00) 0.95 |
1.47(0.69-3.15) 0.99 |
0.71(0.48-1.03) 0.94 |
1.03(0.89-1.20) 0.90 |
0.69 | 0.27 |
| rs1801282 C |
3 PPARG |
1.14(0.88-1.48) 0.87 |
0.70(0.39-1.26) 0.98 |
1.06(0.55-2.04) 0.94 |
0.83(0.54-1.28) 0.97 |
1.15(0.84-1.57) 0.89 |
1.04(0.88-1.23) 0.93 |
0.63 | 0.41 |
| rs4607103 C |
3 ADAMTS9 |
0.86(0.71-1.04) 0.74 |
0.99(0.81-1.22) 0.71 |
0.89(0.64-1.22) 0.74 |
0.95(0.80-1.13) 0.65 |
0.99(0.80-1.22) 0.68 |
0.94(0.86-1.03) 0.70 |
0.20 | 0.81 |
| rs4402960 T |
3 IGF2BP2 |
0.91(0.76-1.08) 0.34 |
1.07(0.88-1.30) 0.49 |
0.89(0.64-1.23) 0.28 |
0.91(0.76-1.08) 0.33 |
1.16(0.92-1.45) 0.26 |
0.98(0.89-1.07) 0.34 |
0.61 | 0.30 |
| rs10010131 G |
4 WFS1 |
1.01(0.86-1.20) 0.59 |
0.91(0.74-1.12) 0.67 |
0.86(0.60-1.23) 0.80 |
1.14(0.68-1.89) 0.98 |
0.96(0.78-1.19) 0.70 |
0.97(0.87-1.07) 0.76 |
0.55 | 0.82 |
| rs7754840 C |
6 CDKAL1 |
1.02(0.85-1.20) 0.31 |
1.10(0.91-1.34) 0.54 |
1.04(0.78-1.38) 0.52 |
1.06(0.90-1.25) 0.43 |
1.00(0.81-1.23) 0.32 |
1.05(0.96-1.14) 0.42 |
0.29 | 0.97 |
| rs864745 A |
7 JAZF1 |
0.93(0.78-1.09) 0.53 |
0.87(0.71-1.07) 0.74 |
0.81(0.59-1.10) 0.72 |
1.02(0.84-1.23) 0.78 |
1.01(0.83-1.24) 0.62 |
0.94(0.86-1.03) 0.68 |
0.17 | 0.68 |
| rs13266634 C |
8 SLC30A8 |
1.00(0.83-1.20) 0.71 |
0.78(0.57-1.07) 0.90 |
0.95(0.70-1.28) 0.63 |
1.05(0.89-1.24) 0.63 |
1.04(0.82-1.31) 0.75 |
1.00(0.90-1.10) 0.72 |
0.91 | 0.60 |
| rs2383208 A |
9 CDKN2B |
1.01(0.81-1.25) 0.81 |
1.06(0.83-1.34) 0.80 |
0.98(0.71-1.35) 0.74 |
1.07(0.91-1.26) 0.57 |
0.96(0.73-1.27) 0.86 |
1.03(0.93-1.13) 0.74 |
0.62 | 0.92 |
| rs1111875 G |
10 HHEX |
1.01(0.85-1.20) 0.60 |
1.16(0.93-1.46) 0.75 |
1.09(0.79-1.52) 0.30 |
1.20(1.00-1.44) 0.26 |
0.94(0.76-1.16) 0.63 |
1.07(0.98-1.18) 0.50 |
0.15 | 0.48 |
| rs7903146 T |
10 TCF7L2 |
1.06(0.89-1.28) 0.29 |
1.00(0.81-1.23) 0.27 |
1.16(0.77-1.73) 0.14 |
1.05(0.72-1.55) 0.045 |
1.00(0.79-1.27) 0.22 |
1.03(0.92-1.15) 0.19 |
0.59 | 0.98 |
| rs12779790 C |
10 CDC123 |
0.88(0.71-1.10) 0.17 |
0.97(0.74-1.26) 0.14 |
1.15(0.80-1.64) 0.18 |
1.21(0.97-1.49) 0.16 |
0.98(0.76-1.27) 0.17 |
1.03(0.92-1.15) 0.16 |
0.63 | 0.33 |
| rs2237895d C |
11 KCNQ1 |
0.99(0.83-1.18) 0.42 |
0.98(0.77-1.25) 0.21 |
0.94(0.68-1.31) 0.36 |
1.06(0.88-1.32) 0.35 |
1.00(0.80-1.27) 0.42 |
1.00(0.90-1.10) 0.35 |
0.93 | 0.96 |
| rs2237897d C |
11 KCNQ1 |
1.01(0.68-1.49) 0.95 |
1.13(0.80-1.59) 0.92 |
1.13(0.77-1.67) 0.78 |
0.92(0.75-1.13) 0.62 |
0.97(0.74-1.26) 0.78 |
1.00(0.89-1.13) 0.80 |
1.00 | 0.016 |
| rs5219 T |
11 KCNJ11 |
1.07(0.90-1.28) 0.35 |
0.77(0.55-1.08) 0.10 |
1.01(0.75-1.37) 0.38 |
0.81(0.68-0.95) 0.39 |
0.77(0.63-0.96) 0.39 |
0.89(0.81-0.97) 0.32 |
0.012 | 0.082 |
| rs7961581 C |
12 TSPAN8 |
0.96(0.79-1.17) 0.27 |
0.95(0.75-1.20) 0.21 |
1.10(0.80-1.51) 0.28 |
1.01(0.82-1.24) 0.20 |
1.27(1.00-1.60) 0.20 |
0.94(0.76-1.15) 0.23 |
0.60 | 0.39 |
| rs8050136 A |
16 FTO |
0.86(0.72-1.02) 0.42 |
0.89(0.73-1.08) 0.44 |
0.63(0.43-0.93) 0.24 |
1.07(0.88-1.30) 0.21 |
0.96(0.77-1.19) 0.28 |
0.91(0.83-1.00) 0.32 |
0.055 | 0.21 |
| Obesity SNPs | |||||||||
| rs2815752 A |
1 NEGR1 |
1.00(0.85-1.19) 0.63 |
1.10(0.90-1.34) 0.54 |
1.04(0.70-1.56) 0.83 |
0.85(0.64-1.14) 0.93 |
1.06(0.85-1.31) 0.71 |
1.02(0.92-1.13) 0.73 |
0.70 | 0.63 |
| rs10913469 C |
1 SEC16B |
0.99(0.80-1.23) 0.18 |
0.87(0.70-1.08) 0.28 |
0.57(0.38-0.85) 0.21 |
1.20(1.00-1.44) 0.23 |
0.89(0.70-1.14) 0.20 |
0.96(0.86-1.06) 0.22 |
0.38 | 0.016 |
| rs6548238 T |
2 TMEM18 |
1.08(0.87-1.34) 0.17 |
1.07(0.80-1.44) 0.11 |
0.59(0.31-1.13) 0.079 |
1.15(0.89-1.49) 0.10 |
1.17(0.88-1.56) 0.13 |
1.08(0.95-1.22) 0.12 |
0.23 | 0.40 |
| rs10938397 G |
4 GNPDA2 |
0.93(0.78-1.10) 0.42 |
0.81(0.64-1.02) 0.25 |
1.14(0.83-1.55) 0.28 |
0.97(0.81-1.16) 0.29 |
1.08(0.88-1.32) 0.35 |
0.97(0.89-1.06) 0.32 |
0.50 | 0.34 |
| rs925946e T |
11 BDNF |
0.92(0.76-1.12) 0.29 |
1.01(0.81-1.26) 0.28 |
1.73(1.19-2.53) 0.18 |
1.12(0.70-1.77) 0.030 |
0.90(0.70-1.15) 0.23 |
1.02(0.91-1.14) 0.19 |
0.78 | 0.24 |
| rs6265e C |
11 BDNF |
1.33(1.06-1.68) 0.79 |
1.32(0.85-2.05) 0.94 |
0.70(0.51-0.97) 0.68 |
0.92(0.78-1.09) 0.60 |
0.91(0.70-1.19) 0.85 |
1.01(0.91-1.12) 0.76 |
0.88 | 0.049 |
| rs10838738 G |
11 MTCH2 |
0.99(0.83-1.19) 0.34 |
1.16(0.86-1.56) 0.11 |
0.96(0.70-1.33) 0.32 |
0.99(0.83-1.17) 0.34 |
1.17(0.96-1.43) 0.35 |
1.05(0.95-1.15) 0.29 |
0.36 | 0.58 |
| rs7138803 A |
12 BCDIN3D |
0.93(0.78-1.10) 0.39 |
0.97(0.77-1.23) 0.19 |
0.97(0.68-1.38) 0.19 |
1.06(0.90-1.26) 0.34 |
0.97(0.78-1.21) 0.26 |
0.99(0.90-1.09) 0.29 |
0.83 | 0.90 |
| rs7498665 G |
16 SH2B1 |
0.82(0.69-0.97) 0.40 |
1.03(0.84-1.26) 0.27 |
1.03(0.75-1.41) 0.28 |
1.00(0.79-1.27) 0.13 |
0.87(0.72-1.06) 0.45 |
0.92(0.83-1.01) 0.30 |
0.073 | 0.47 |
| rs8050136 A |
16 FTO |
0.87(0.74-1.03) 0.42 |
0.91(0.75-1.10) 0.44 |
0.60(0.41-0.86) 0.24 |
1.04(0.86-1.26) 0.21 |
0.96(0.78-1.19) 0.28 |
0.92(0.84-1.00) 0.32 |
0.055 | 0.21 |
| rs17782313 C |
18 MC4R |
0.97(0.80-1.19) 0.22 |
0.98(0.80-1.20) 0.29 |
1.00(0.65-1.52) 0.13 |
0.95(0.79-1.15) 0.23 |
0.92(0.68-1.23) 0.13 |
0.98(0.88-1.08) 0.21 |
0.63 | 0.98 |
| rs11084753 G |
19 KCTD15 |
0.89(0.75-1.07) 0.68 |
1.12(0.92-1.36) 0.64 |
1.04(0.78-1.39) 0.42 |
1.03(0.87-1.22) 0.29 |
0.96(0.79-1.18) 0.67 |
1.00(0.91-1.09) 0.53 |
0.97 | 0.53 |
| rs29941 G |
19 KCTD15 |
0.90(0.75-1.08) 0.69 |
1.11(0.86-1.42) 0.82 |
0.87(0.65-1.17) 0.40 |
1.05(0.87-1.27) 0.21 |
0.81(0.66-1.00) 0.66 |
0.94(0.85-1.03) 0.54 |
0.18 | 0.26 |
a
OR adjusted for age(quartiles), BMI(quartiles), diabetes status (self-report) and ethnicity (in pooled analysis).
b
NCBI build 36 (forward strand).
c
P value for heterogeneity between risk allele and ethnic groups (4-df).
d
Rs2237895 and rs2237897 adjusted for each other.
e
Rs925946 and rs6265 adjusted for each other.