Table 1.
EUCAST and CLSI antifungal breakpoint comparison for major Candida species1
| Antifungal agent |
MIC breakpoint (mg/L) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Candida albicans |
Candida glabrata |
Candida krusei |
Candida parapsilosis |
Candida tropicalis | ||||||
| S≤ | R> | S≤ | R> | S≤ | R> | S≤ | R> | S≤ | R> | |
| Anidulafungin | ||||||||||
| EUCAST | 0.03 | 0.03 | 0.06 | 0.06 | 0.06 | 0.06 | 0.002 | 4 | 0.06 | 0.06 |
| CLSI | 0.25 | 0.5 | 0.12 | 0.25 | 0.25 | 0.5 | 2 | 4 | 0.25 | 0.5 |
| Caspofungin | ||||||||||
| EUCAST | ND2 | ND | ND | ND | ND | ND | ND | ND | ND | ND |
| CLSI | 0.25 | 0.5 | 0.12 | 0.25 | 0.25 | 0.5 | 2 | 4 | 0.25 | 0.5 |
| Micafungin | ||||||||||
| EUCAST | 0.016 | 0.016 | 0.03 | 0.03 | IE3 | IE | 0.002 | 2 | IE | IE |
| CLSI | 0.25 | 0.5 | 0.06 | 0.125 | 0.25 | 0.5 | 2 | 4 | 0.25 | 0.5 |
1
Adapted from Arendrup et al. [114]
2
ND- Not determined due to significant inter-laboratory variation in MIC ranges
3
IE- Insufficient evidence (IE) due to small number of cases