Table III.
Determination of analyte recovery of xanthohumol (XN) and its metabolites (isoxanthohumol [IX]; 8-prenylnaringenin [8PN]; and 6-prenylnaringenin [6PN]) at low, medium, and high concentrations using paper strip extraction with human plasma and urine as biological matrices (n = 5 per concentration level)*
| Standards | |||||||
|---|---|---|---|---|---|---|---|
| Human Plasma | Human Urine | ||||||
| Analytes | Low Conc. 5nM | Medium Conc. 50 nM | High Conc. 400 nM | Low Conc. 5nM | Medium Conc. 50 nM | High Conc. 400 nM | |
| XN | %Recovery | 76 ± 8 | 66 ± 8 | 67 ± 2 | 65 ± 5 | 87 ± 10 | 101 ± 10 |
| % RSD | 10 | 13 | 3 | 7 | 11 | 10 | |
| IX W | %Recovery | 105 ± 11 | 89 ± 6 | 88 ± 7 | 117 ± 9 | 109 ± 8 | 108 ± 4 |
| % RSD | 10 | 8 | 7 | 7 | 4 | ||
| 8PN | %Recovery | 95 ± 7 | 87 ± 10 | 85 ± 8 | 111 ± 8 | 100 ± 6 | 105 ± 4 |
| % RSD | 8 | 12 | 9 | 7 | 6 | 4 | |
| 6PN | %Recovery | 81 ± 5 | 74 ± 5 | 68 ± 5 | 109 ± 4 | 108 ± 10 | 110 ± 3 |
| % RSD | 6 | 7 | 7 | 3 | 9 | 2 | |
*
Values are mean ± standard deviation