Table 2.
Summary of significant associations between pathway genes and breast cancer risk by percent Native American ancestry
| <=28% Native American Ancestry | >28 – 70% Native American Ancestry | >70% Native American Ancestry | Interaction P-value (raw; adjusted)2 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| Controls | Cases | OR1 (95% CI) | Controls | Cases | OR (95% CI) | Controls | Cases | OR (95% CI) | ||
| CD40LG (rs1126535) | 0.014, 0.036 | |||||||||
| TT | 1232 | 1136 | 1.00 | 516 | 457 | 1.00 | 81 | 68 | 1.00 | |
| TC | 552 | 526 | 1.05 (0.90, 1.21) | 824 | 662 | 0.91 (0.77, 1.07) | 291 | 182 | 0.77 (0.52, 1.13) | |
| CC | 57 | 78 | 1.47 (1.03, 2.10) | 337 | 270 | 0.94 (0.76, 1.16) | 256 | 187 | 0.96 (0.65, 1.41) | |
| P-value (raw; adjusted) 2 | 0.032, 0.083 | 0.576, 0.940 | 0.821, 1.000 | |||||||
| CD40LG (rs5930973) | 0.022, 0.036 | |||||||||
| GG | 1637 | 1560 | 1.00 | 1630 | 1327 | 1.00 | 623 | 433 | 1.00 | |
| GA/AA | 205 | 182 | 0.93 (0.75, 1.15) | 49 | 63 | 1.63 (1.11, 2.40) | 6 | 4 | 0.79 (0.21, 2.94) | |
| P-value (raw; adjusted) | 0.519, 0.855 | 0.014, 0.036 | 0.730, 1.000 | |||||||
| TLR1 (rs7696175) | <.001, <.001 | |||||||||
| CC/CT | 1472 | 1444 | 1.00 | 1462 | 1174 | 1.00 | 550 | 355 | 1.00 | |
| TT | 370 | 298 | 0.82 (0.69, 0.97) | 215 | 216 | 1.25 (1.01, 1.53) | 78 | 82 | 1.77 (1.25, 2.51) | |
| P-value (raw; adjusted) | 0.020, 0.020 | 0.038, 0.038 | 0.001, 0.001 | |||||||
| TLR2 (rs4696483) | 0.012, 0.036 | |||||||||
| CC/CT | 1796 | 1714 | 1.00 | 1637 | 1352 | 1.00 | 617 | 422 | 1.00 | |
| TT | 46 | 27 | 0.61 (0.38, 0.99) | 42 | 38 | 1.13 (0.72, 1.78) | 12 | 15 | 1.83 (0.84, 4.00) | |
| P-value (raw; adjusted) | 0.047, 0.142 | 0.583, 1.000 | 0.131, 0.392 | |||||||
| TNFRSF11A (rs8099222) | 0.227, 1.000 | |||||||||
| GG | 1055 | 994 | 1.00 | 1028 | 877 | 1.00 | 494 | 320 | 1.00 | |
| GA | 681 | 640 | 1.00 (0.87, 1.15) | 546 | 453 | 0.97 (0.83, 1.13) | 131 | 102 | 1.11 (0.82, 1.50) | |
| AA | 97 | 92 | 1.01 (0.75, 1.36) | 103 | 60 | 0.69 (0.49, 0.96) | 4 | 15 | 4.66 (1.51, 14.40) | |
| P-value (raw; adjusted) | 0.970, 1.000 | 0.028, 0.493 | 0.008, 0.133 | |||||||
| TNFRSF11A (rs8089829) | 0.004, 0.070 | |||||||||
| AA | 525 | 532 | 1.00 | 644 | 499 | 1.00 | 324 | 203 | 1.00 | |
| AG | 916 | 826 | 0.88 (0.75, 1.02) | 759 | 653 | 1.11 (0.95, 1.31) | 272 | 189 | 1.06 (0.82, 1.38) | |
| GG | 398 | 380 | 0.94 (0.78, 1.13) | 274 | 236 | 1.10 (0.89, 1.36) | 33 | 44 | 1.92 (1.17, 3.16) | |
| P-value (raw; adjusted) | 0.495, 1.000 | 0.381, 1.000 | 0.010, 0.161 | |||||||
1
Odds Ratios (OR) and 95% Confidence Intervals (CI) adjusted for age, study, BMI during referent year, parity, and genetic ancestry.
2
P values in table for SNPs are unadjusted and adjusted for multiple comparisons using the step down Bonferroni correction. ARTPp for <=28% NA ancestry = 0.267 for CD40LG, 0.019 for TLR1, 0.205 for TLR2, and 0.93 for TNFRSF11A; for >28–70% NA ancestry = 0.0498 for CD40LG, 0.037 for TLR1, 0.822 for TLR2 and 0.348 for TNFRSF11A; for >70% NA ancestry CD40LG = 0.762, TLR1 = 0.0008, TLR2= 0.446, and TNFRSF11A = 0.176. Pathway p value only significant for >70% NA = 0.015.