Table 5.
Associations between genes and breast cancer-specific mortality by percent Native American Ancestry.
| ≤28% Native American Ancestry | >28% Native American Ancestry | Interaction P-value (raw, adjusted)2 | |||||
|---|---|---|---|---|---|---|---|
| Deaths/Person Years | HR1 (95% CI) | Deaths/Person Years | HR (95% CI) | Deaths/Person Years | HR (95% CI) | ||
| TLR1 (rs7696175)3 | 0.880, 0.880 | ||||||
| CC/CT | 198 / 20050 | 1.00 | 114 / 11827 | 1.00 | 84 / 8223 | 1.00 | |
| TT | 51 / 3708 | 1.40 (1.03, 1.91) | 31 / 2374 | 1.40 (0.94, 2.09) | 20 / 1334 | 1.48 (0.91, 2.42) | |
| P-value (raw; adjusted)2 | 0.032, 0.032 | 0.100, 0.100 | 0.116, 0.116 | ||||
| TLR4 (rs5030728) | 0.252, 1.000 | ||||||
| GG | 114 / 12578 | 1.00 | 65 / 6971 | 1.00 | 49 / 5608 | 1.00 | |
| GA | 106 / 9413 | 1.24 (0.95, 1.61) | 64 / 6015 | 1.18 (0.83, 1.66) | 42 / 3398 | 1.32 (0.87, 2.01) | |
| AA | 29 / 1767 | 1.96 (1.30, 2.95) | 16 / 1216 | 1.59 (0.92, 2.76) | 13 / 552 | 2.70 (1.46, 5.01) | |
| P-value (raw; adjusted) | 0.001, 0.008 | 0.096, 0.506 | 0.002, 0.010 | ||||
| TNFRSF1A (rs4149578) | 0.356, 1.000 | ||||||
| GG/GA | 240 / 23463 | 1.00 | 140 / 14012 | 1.00 | 100 / 9451 | 1.00 | |
| AA | 7 / 253 | 2.71 (1.27, 5.76) | 4 / 174 | 1.97 (0.72, 5.37) | 3 / 80 | 4.34 (1.34, 14.06) | |
| P-value (raw; adjusted) | 0.010, 0.029 | 0.184, 0.553 | 0.014, 0.043 | ||||
| TNFSF10 (rs231985) | 0.348, 1.000 | ||||||
| AA/AT | 243 / 23464 | 1.00 | 143 / 13979 | 1.00 | 100 / 9486 | 1.00 | |
| TT | 5 / 219 | 2.99 (1.23, 7.28) | 2 / 169 | 2.15 (0.52, 8.78) | 3 / 50 | 5.26 (1.63, 16.93) | |
| P-value (raw; adjusted) | 0.016, 0.096 | 0.288, 0.622 | 0.005, 0.038 | ||||
| TNFSF10 (rs3136597) | 0.354, 1.000 | ||||||
| CC | 153 / 15330 | 1.00 | 81 / 8852 | 1.00 | 72 / 6478 | 1.00 | |
| CA | 78 / 7407 | 1.14 (0.86, 1.50) | 53 / 4694 | 1.34 (0.94, 1.89) | 25 / 2713 | 0.88 (0.55, 1.40) | |
| AA | 18 / 1021 | 2.01 (1.23, 3.29) | 11 / 655 | 2.14 (1.13, 4.06) | 7 / 366 | 1.99 (0.91, 4.36) | |
| P-value (raw; adjusted) | 0.006, 0.039 | 0.020, 0.140 | 0.084, 0.508 | ||||
| TNFSF10 (rs231983) | 0.326, 1.000 | ||||||
| CC | 48 / 5967 | 1.00 | 17 / 2607 | 1.00 | 31 / 3360 | 1.00 | |
| CA/AA | 200 / 17713 | 1.44 (1.04, 1.98) | 128 / 11541 | 1.76 (1.06, 2.92) | 72 / 6172 | 1.28 (0.83, 1.97) | |
| P-value (raw; adjusted) | 0.027, 0.138 | 0.030, 0.179 | 0.269, 1.000 | ||||
1
Breast cancer survival among primary invasive cases; Hazard Ratios (HR) and 95% Confidence Intervals (CI) adjusted for age, study, BMI during referent year, genetic ancestry, and SEER summary stage. Deaths are for breast cancer deaths only; other causes of death are censored.
2
P values for SNPs are unadjusted and adjusted for multiple comparisons using the step down Bonferroni correction.
3
ARTP p values for genes among all cases: TLR1 = 0.037; TLR4 = 0.032; TNFRSF1A= 0.151; TNFSF10= 0.122. Pathway p value is 0.152.