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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Immunotherapy. 2014;6(6):755–774. doi: 10.2217/imt.14.37

Figure 4. Design of a peptidomimetic for immunomodulation.

Figure 4

(A) Based on the hot-spot region of F and C strands of CD2 protein that binds to CD58, epitopes of secondary structure of CD2 protein were chosen. (B) Epitopes of CD2 protein from the adhesion domain that have β-strand and β-turn structures. (C) Based on F and C strands, a peptide was designed with backbone cyclization and insertion of β-hairpin, β-turn inducer DBF [3,40,46].

DBF: Dibenzofuran.