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Steady-state plasma concentrations (mean ± S.E.M.) of bupropion (BUP) (A) and its metabolites OH-BUP (B), EB (C), and TB (D) over 24 hours by CYP2C19*2 genotype. The *1/*1 group (n = 17) represents individuals without any CYP2C19*2, *3, or *17 allele. The *1/*2 group represents individuals with one copy of CYP2C19*2 (n = 15). The P values were derived from the linear regression analyses presented in Table 1, which include five people with CYP2C19*2/*17 genotype.
