Fig. 3.

Steady-state plasma concentrations (mean ± S.E.M.) of bupropion (BUP) (A) and its metabolites OH-BUP (B), EB (C), and TB (D) over 24 hours by CYP2C19*17 genotype. The *1/*1 group (n = 17) represents individuals without any known CYP2C19*2, *3, or *17 alleles. The *1/*17 and *17/*17 groups represent individuals with one or two copies of CYP2C19*17 (n = 15; there was one individual with the *17/*17 genotype). There were no significant effects as described by the linear regression analyses presented in Table 1, which include five people with CYP2C19*2/*17 genotype.