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. 2014 Nov;86(5):492–504. doi: 10.1124/mol.114.093468

Fig. 1.

Fig. 1.

Functional interaction between mGluR5 and mGluR1 Y74A. (A) Calcium current amplitude time courses (left) and sample representative current traces (right) illustrating the effect of various concentrations of Glu (as indicated) in SCG neurons expressing mGluR5b (upper panel), mGluR1 Y74A (center panel), and both receptors (lower panel). The voltage protocol, a 25-millisecond step to +10 mV near the peak current from a holding potential of −80 mV, for the current traces is shown in (A) (upper right panel). (B and C) Average (± S.E.M.) responses at a range of [Glu]s from SCG neurons expressing mGluR5 alone (circles), mGluR1 Y74A alone (squares), or both receptors together (diamonds). Panel (B) shows a set of experiments using the mGluR5b splice variant, and (C) shows experiments using the mGluR5a splice variant. Numbers of cells for each point are given in the text. Solid and hatched lines show the results of fits to the Hill equation. Con, control.