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. 2014 Nov;86(5):492–504. doi: 10.1124/mol.114.093468

Fig. 2.

Fig. 2.

The interaction between mGluR1 and mGluR5 is reciprocal, and mGluR1 does not interact functionally with mGluR2. (A) Average (± S.E.M.) Glu dose-response relationship of calcium current inhibition in SCG neurons in cells expressing mGluR1 alone (filled squares), mGluR5b Y64A alone (filled circles), or both receptors together (open squares). Fits to the Hill equation are shown as solid or hatched lines, yielding EC50 values of 1, 56, and 16 µM for mGluR1, mGluR5 Y64A, and both receptors together, respectively. (B) Average (± S.E.M.) Glu dose-response relationship of calcium current inhibition in SCG neurons in cells expressing mGluR1aY74A alone (filled squares), mGluR1b Y64A alone (filled diamonds), or both receptors together (open diamonds). Fits to the Hill equation are shown as solid or hatched lines, yielding EC50 values of 351, 2, and 118 µM for mGluR1aYA, mGluR1b, and both receptors together, respectively (assuming maximal responses of 60% for mGluR1aYA and 66% for both receptors together). (C) Average (± S.E.M.) Glu dose-response relationship of calcium current inhibition in SCG neurons in cells expressing mGluR1 Y64A alone (filled squares), mGluR2 alone (filled circles), or both receptors together (open squares). Fits to the Hill equation are shown as solid lines, yielding EC50 values of 5 and 980 µM for mGluR2 and mGluR1 Y74A, respectively. Due to the complex shape, the data from cells with both receptors coexpressed were not fit.