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. 2014 Nov;86(5):492–504. doi: 10.1124/mol.114.093468

Fig. 3.

Fig. 3.

Selective NAMs strongly inhibit signaling of combined mGluR YA/mGluR wild-type signaling. (A) Neurons coexpressing mGluR5 Y64A and mGluR1 are strongly inhibited by 1 µM MPEP. Average (± S.E.M.) calcium current inhibition produced by indicated [glutamate] in cells coexpressing mGluR5YA with mGluR1 in the absence (filled triangles; n = 5) and presence (open triangles; n = 4) of 1 µM MPEP. (B) Average (± S.E.M.) calcium current inhibition produced by indicated [glutamate] in cells coexpressing mGluR5 with mGluR1YA in the absence (filled squares; n = 5) and presence (open squares; n = 6) of 1 µM BAY36. (C), Average (± S.E.M.) calcium current inhibition produced by indicated [glutamate] in cells coexpressing mGluR5YA with mGluR1 in the absence (filled diamonds; n = 12 at 1 mM, n = 7 at 100 µM) and presence (open diamonds; n = 12 at 10 µM, n = 5 at all other [Glu]s) of 1 µM BAY36. (D) Average (± S.E.M.) calcium current inhibition produced by indicated [glutamate] in cells coexpressing mGluR5 with mGluR1YA in the absence (filled diamonds; n = 6) and presence (open diamonds; n = 5 at 10 µM, n = 6 at all other [Glu]s) of 1 µM MPEP.