Fig. 2.

Bexarotene inhibits SM hypertrophy. (A) SMCs were pretreated with bexarotene for 24 hours, and [³H]leucine was added for an additional 24 hours. [³H]Leucine incorporation was measured as described in Materials and Methods. (B) After bexarotene pretreatment, cells were collected at indicated time points after AII treatment and subjected to Western blotting for p-4EBP1. β-Actin was used as a loading control. Representative blot shown; fold changes in densitometry measurements ± S.E.M. are shown in graph. *P < 0.05 versus DMSO.