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Bexarotene inhibits p38 activation downstream of MKK3/6. (A) SMCs were cotransfected with constitutively active MKK3/6 or control (pCDNA) and calponin-luciferase reporter. After pretreatment with bexarotene, cells were stimulated for 48 hours with AII. Luciferase activity normalized to β-galactosidase was determined. P = 0.06 ca-MKK3/6-DMSO versus caMKK3/6-BEX. (B) The qRT-PCR showing increased levels of DUSP4, DUSP5, and DUSP10. *P < 0.05 versus DMSO.
