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. 2014 Oct 17;5:173. doi: 10.3389/fendo.2014.00173

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Copyright © 2014 Capri, Yani, Chattat, Fortuna, Bucci, Lanzarini, Morsiani, Catena, Ansaloni, Adversi, Melotti, Di Nino and Franceschi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre-, intra-, and post-operative risk factors were evaluated in univariate and multivariate analyses, depicted as a funnel; the numbers reported in the figure are referred to the previous work (14). In this paper, by means of a sub-cohort of 74 patients (37 controls and 37 with POD), pre-operative IL-6 plasma level (≥9 pg/mL) and age were found to be independent risk factors together with other pre-operative parameters, i.e., CIRS (cumulative illness rating scale), SPMSQ (short-portable mental status questionnaire), HADS (hospital anxiety and depression scale) showing that pre-operative variables are the most significant to predict POD onset.