Table 1.

Bone parameters measured using high-resolution μCT.

	P58IPK-null		Wild-type
	Tibia	Femur	Tibia	Femur
TV (mm3)
12–13 months	$\begin{array}{c}0.404\pm 0.014\\ 0.397\pm 0.013\end{array}\}**$	$\begin{array}{c}0.416\pm 0.010\\ 0.394\pm {0.014}^{\text{a}}\end{array}\}*$	0.472 ± 0.024	0.437 ± 0.031
23–25 months			0.450 ± 0.013	0.484 ± 0.022
BV (mm3)
12–13 months	$\begin{array}{c}0.231\pm 0.012\\ 0.175\pm {0.009}^{\text{a}}\end{array}\}***$	$\begin{array}{c}0.194\pm 0.008\\ 0.150\pm {0.008}^{\text{b}}\end{array}\}***$	0.276 ± 0.007	0.224 ± 0.019
23–25 months			0.248 ± 0.029	0.239 ± 0.016
BV/TV (%)
12–13 months	$\begin{array}{c}57.37\pm 2.84\\ 44.17\pm 2.21\end{array}\}*$	$\begin{array}{c}46.70\pm 2.75\\ 37.95\pm {1.39}^{\text{a}}\end{array}\}**$	58.59 ± 2.21	51.10 ± 1.51
23–25 months			55.52 ± 7.12	49.47 ± 3.87
MV (mm3)
12–13 months	0.172 ± 0.013	0.222 ± 0.017	0.197 ± 0.020	0.213 ± 0.014
23–25 months	0.222 ± 0.013	0.244 ± 0.010	0.201 ± 0.034	0.245 ± 0.025

Bone parameters obtained from μCT analysis of a ROI incorporating 25 lines (0.25 mm) starting from the central line of the epiphyses and moving proximally for the femur and distally for the tibia.

TV, total volume within the periosteal envelope; BV, bone volume; BV/TV, bone volume fraction; MV, marrow volume.

Data represented as mean ± SEM (n = 3–5). Significant differences were detected by GLM ANOVA and Tukey’s post hoc test. Genotype effects are shown *p < 0.05; **p < 0.01; ***p < 0.001 compared to the same compartment in wild-type mice.

Age effects are shown ^ap < 0.05; ^bp < 0.01 compared to the same compartment in age-matched wild-type mice.