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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Nat Chem. 2014 Apr 20;6(6):542–552. doi: 10.1038/nchem.1924

Figure 6. Cytochrome c (cyt c)/H2O2 induces oxidation of polyunsaturated fatty acid (PUFA) residues of cardiolipin (CL) isolated from mouse brain.

Figure 6

a, Characterization of polyunsaturated fatty acids (PUFA) esterified to brain CL. Number of CL molecular species containing PUFA (left). PUFA distribution in brain CL species (right). b, c, MS spectra (b) and quantitative assessment of brain CL molecular species (c) obtained before (red) and after (blue) treatment with cyt c in the presence of H2O2. d, Quantitative assessment of PUFA of non-oxidized CL (red) and CL exposed to cyt c/H2O2 (blue). *p < 0.05 vs control (CL not treated with cyt c). Data are means ± S.D., n=3.