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Effects of CMS on locomotion and central activity in the open field test. The animals were allowed to explore the open field arena for 10 min. (A) Total distance moved (cm), (B) % of time spent in the center, (C) % of entries into the center in ICR and C57BL/6 mice. Data are presented as means ± SEMs (n=10–12/group). *p<0.05, **p<0.01 and ***p<0.001 compared to the corresponding control (two-way ANOVA, Bonferroni post-test).
