Fig. 1.

CPP route determination. Effects of subcutaneously (s.c.) or intraperitoneally (i.p.) injected nicotine on the CPP test. (A) Both s.c and i.p. injected nicotine produced CPP at 0.1 and 0.2 mg/kg dose, but only in adolescent rats. Although not significant, the CPP induced by s.c. injected nicotine is somewhat higher than i.p. (B) The locomotor activity during the conditioning phase of CPP. Although not significant, rats injected with s.c. nicotine showed higher distance moved than those injected by i.p. The values are presented means and S.E.M. **p<0.01, ***p<0.001 statistically significant vs. the control group (Dunnet’s posttest).