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. 2014 Nov;351(2):344–351. doi: 10.1124/jpet.114.218123

Fig. 3.

Fig. 3.

C3a and C5a receptor antagonists do not reverse decreased free plasma VEGF or average fetal weight following placental ischemia. Sham or RUPP animals were treated with Veh, C3aRA, or C5aRA from GD 14–18. Values represent geometric mean ± S.E. of VEGF in GD 19 plasma or fetal weight measured at GD 19. (A) Decrease in VEGF in the RUPP Veh group (n = 23) was not affected by the C3aRA (n = 12) or C5aRA (n = 11). Free plasma VEGF at GD 19 did not differ between Sham animals treated with Veh (n = 19), C3aRA (n = 6), or C5aRA (n = 5). (B) Decrease in fetal weight in the RUPP Veh group (n = 22) was not affected by the C3aRA (n = 11) or C5aRA (n = 10). Fetal weight did not differ between Sham animals treated with Veh (n = 19), C3aRA (n = 6), or C5aRA (n = 5). *P < 0.05 for indicated comparisons.