TABLE 1.
General characteristics of DS rats on a HF/HS diet following 4 weeks of treatment with vehicle control, the ETA receptor antagonist, ABT-627, and/or the diuretic, CLTD
| Control | ABT | CLTD | ABT + CLTD | |
|---|---|---|---|---|
| Food intake (g/day) | 14 ± 2 | 14 ± 1 | 15 ± 1 | 17 ± 2 |
| Water intake (ml/day) | 75 ± 9 | 70 ± 7 | 60 ± 4 | 62 ± 3 |
| Urine volume (ml/day) | 72 ± 10 | 65 ± 9 | 50 ± 2 | 48 ± 2 |
| Sodium excretion (mmol/day) | 24.5 ± 3.3 | 25.1 ± 3.4 | 24.8 ± 2.2 | 21.3 ± 0.6 |
| Creatinine clearance (ml/min) | 0.67 ± 0.15 | 0.90 ± 0.24 | 0.64 ± 0.20 | 0.33 ± 0.10 |
| Plasma sodium (mmol/l) | 135 ± 2 | 140 ± 1 | 140 ± 1 | 142 ± 1 |
| Body weight (g) | 349 ± 10 | 369 ± 12 | 374 ± 5 | 385 ± 13 |
| Kidney weight (g/100 g b.wt.) | 0.57 ± 0.04 | 0.60 ± 0.02 | 0.49 ± 0.01† | 0.47 ± 0.01† |
| Heart weight (g/100 g b.wt.) | 0.42 ± 0.01 | 0.403 ± 0.004* | 0.29 ± 0.06† | 0.35 ± 0.01 |
| Number of rats | 7 | 7 | 6 | 6 |
*
P < 0.05 versus control; †P < 0.05 versus ABT.