TABLE 2.
Metabolic characteristics of DS rats on a HF/HS diet following 4 weeks of treatment with vehicle control, the ETA receptor antagonist, ABT-627, and/or the diuretic, CLTD
| Control | ABT | CLTD | ABT + CLTD | |
|---|---|---|---|---|
| Plasma glucose (mg/dl) | 355 ± 35 | 292 ± 51 | 273 ± 30 | 242 ± 32 |
| Plasma insulin (ng/ml) | 0.86 ± 22 | 1.53 ± 0.44 | 1.76 ± 0.34 | 1.90 ± 0.20 |
| Total cholesterol (mg/dl) | 129 ± 18 | 109 ± 9 | 82 ± 1 | 95 ± 9 |
| Triglyceride (mg/dl) | 75 ± 16 | 67 ± 23 | 66 ± 19 | 107 ± 23 |
| Free fatty acid (mmol/l) | 164 ± 34 | 139 ± 52 | 103 ± 20 | 190 ± 45 |
| Epididymal fat (g/100 g b.wt.) | 0.41 ± 0.03 | 0.46 ± 0.03 | 0.50 ± 0.03 | 0.48 ± 0.03 |