TABLE 3.
Plasma measurement of inflammatory and oxidative stress markers from DS rats on a HF/HS diet following 4 weeks of treatment with vehicle control, the ETA receptor antagonist, ABT-627, and/or the diuretic, CLTD
| Control | ABT | CLTD | ABT + CLTD | |
|---|---|---|---|---|
| TNF-α (pg/ml) | 0.105 ± 0.001 | 0.103 ± 0.001 | 0.105 ± 0.005 | 0.098 ± 0.002 |
| TNF-R1 (pg/ml) | 943 ± 169 | 536 ± 64 | 538 ± 128 | 412 ± 35* |
| TNF-R2 (pg/ml) | 1571 ± 119 | 1254 ± 50 | 1155 ± 175 | 975 ± 79* |
| 8-OHdG (ng/ml) | 3.6 ± 0.8 | 1.5 ± 0.2* | 2.1 ± 0.2 | 1.6 ± 0.2* |
*
P < 0.05 versus control.