Figure 5.

The effect of mutation at position 195 of Agam\Or15 on odorant sensitivity is not consistent among odorants. CRCs were constructed (see Methods) for 8 odorants at a series of Agam\Or15 receptors with various residues at position 195. EC₅₀ values (mean ± SEM) for 1 odorant at a series of mutants are presented in each panel. (A) propiophenone, (B) 4-methylpropiophenone, (C) acetophenone, (D) 4-methylacetophenone, (E) benzaldehyde, (F) 4-methylbenzaldehyde, (G) phenol, and (H) 4-methylphenol. Numerical values and statistical analyses are provided in Supplementary Table 2.