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C. albicans strains lacking CaYHB1 show attenuated virulence. The His+ Ura+C. albicans strains used were the CAF2, Δyhb1 (yhb1Δ/yhb1Δ ura3Δ/URA3c), and YHB1 reconstituted (yhb1Δ/YHB1c ura3Δ/URA3c) strains shown. Tail vein injection with Candida was performed on day 0.