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. 2014 Oct 16;55(10):6505–6513. doi: 10.1167/iovs.14-14525

Figure 2.

Figure 2

The RGCs expressing EYFP are homogeneously distributed throughout the retina of Thy1-COP4/EYFP transgenic mice. Representative retina whole mount montage showing RGCs evenly distributed throughout the retina of these transgenic mice (A). High magnification blow-out image illustrates RGC soma, dendrites, and axons contain EYFP fluorescence. The EYFP fluorescence is enhanced using anti-GFP antibodies. The mouse eye provides a window to visualize CNS structures in vivo by SD-OCT and CSLO (B–D). Depth-resolving SD-OCT highlights retinal microstructure, such as vessel architecture in the adult mouse retina in vivo (C). The CSLO imaging over the optic nerve head highlights vessels as areas devoid of fluorescence while Thy-1 driven EYFP expression show the RGC soma, dendrites, and axons (D).