Table 2. Silane and Allene Variation.
| entry | R1 | conditions | silane | product (% yield) | regioselectivity (1:2) |
|---|---|---|---|---|---|
| 1 | Cy | A | Me2PhSiH | 1c (90) | >98:2 |
| 2 | Cy | A | Me2EtOSiH | 1d (81) | 96:4 |
| 3 | Ph | A | Me2PhSiH | 6a (83) | >98:2 |
| 4 | Ph | A | Me2EtOSiH | 6b (88) | >98:2 |
| 5 | Ph | A | BnMe2SiH | 6c (90) | >98:2 |
| 6 | BnO | A | Me2PhSiH | 7a (95)a | >98:2 |
| 7 | BnO | A | Me2EtOSiH | 7b (84) | >98:2 |
| 8 | BnO | A | BnMe2SiH | 7c (85) | >98:2 |
| 9 | n-Oct | A | Me2PhSiH | 8a (83) | 98:2 |
| 10 | n-Oct | A | Me2EtOSiH | 8b (87) | 96:4 |
| 11 | n-Oct | A | BnMe2SiH | 8c (91) | 93:7 |
| 12 | Cy | B | BnMe2SiH | 1b (94) | 98:2 |
| 13 | Cy | B | Me2EtOSiH | 1d (99) | 98:2 |
| 14 | Ph | B | Me2EtOSiH | 6b (94) | >98:2 |
| 15 | Ph | B | BnMe2SiH | 6c (92) | >98:2 |
a
Reaction was conducted on a 6.8 mmol scale.