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Model comparing differences in Pt(II) binding preferences within the SRL in vitro and in vivo. Predicted platinum adducts are denoted by “Pt”. Pt(II) binding is conserved throughout the SRL with the exception of the GAGA tetraloop. In vivo, strong Pt(II) targeting to A3027 and G3028 (Pt, orange) is observed. This targeting is not conserved in vitro. Figure generated in PyMOL using PDB files 3O5H and 3O50.
