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. 2014 Aug 4;9(10):2210–2216. doi: 10.1021/cb500492r

Figure 1.

Figure 1

Chemical tools for studying HDAC8. (a) Chemical structures of the HDAC8 inhibitor PCI-34051 and the structurally related negative control compound BRD3811. (b) HDAC inhibitor potencies for PCI-34051, BRD3811, and the pan-inhibitor SAHA. Absolute potency values can be found in Supplementary Table 2. (c) PCI-34051 docked into a crystal structure of HDAC8 (PDB code 1T64). (d) Replacement of the ortho-hydrogen in the docked structure of PCI-34051 (c) with a methyl group. The methyl group protrudes from the enzyme pocket. (e) BRD3811 docked into a crystal structure of HDAC8 (PDB code 1T64).