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| entry | acid | solvent | time (h) | conversion (%)a |
|---|---|---|---|---|
| 1 | TsOH (10%) | H2O | 20 | 0 |
| 2 | TsOH (10%) | THF-H2O | 5 | <5 |
| 3 | HCl (2 M) | ether-H2O | 20 | 30 |
| 4 | HCl (2 M) | THF-H2O | 20 | 35 |
| 5 | H2SO4 (2 M) | AcOH-H2O (1:1)b | 36 | 40 |
| 6 | AcOH (25%)c | CH2Cl2-H2O (4:1)b | 36 | <10 |
| 7 | TFA (2%)c | CH2Cl2-H2O (4:1)b | 36 | <10 |
| 8 | TFA (16%)c | CH2Cl2-H2O (4:1)b | 12 | 100 |
Conversion was measured by 1H NMR.
Volume ratio.
Volume ratio to total solvent.
