Table 3. Estimated presence of nonmotor symptoms in LRRK2 G2019S Parkinson’s disease patients and idiopathic Parkinson’s disease patients in relation to onset of motor symptoms.
| LRRK2-PD | IPD | |
| Loss or change in smell sense; n | 18 | 21 |
| Coincidentally or after OMS (n;%) | 8 (44.4%) | 8 (38.1%) |
| Before OMS (n;%) | 8 (44.4%) | 8 (38.1%) |
| More than 10 yrs before OMS | 2/8 (25%) | 4/8 (50%) |
| Within 10 yrs before OMS | 4/8 (50%) | 2/8 (25%) |
| Within 2 yrs before OMS | 2/8 (25%) | 2/8 (25%) |
| Unknown | 2 (11.1%) | 5 (23.8%) |
| Depression; n | 19 | 12 |
| Coincidentally or after OMS (n;%) | 11 (57.9%) | 7 (58.3%) |
| Before OMS (n;%) | 8 (42.1%) | 5 (41.7%) |
| More than 10 yrs before OMS | 2/8 (25%) | 2/5 (40%) |
| Within 10 yrs before OMS | 3/8 (37.5%) | 2/5 (40%) |
| Within 2 yrs before OMS | 3/8 (37.5%) | 1/5 (20%) |
| Anxiety symptoms; n | 8 | 9 |
| Coincidentally or after OMS (n;%) | 6 (75%) | 1 (11.1%) |
| Before OMS (n;%) | 2 (25%) | 8 (88.9%) |
| More than 10 yrs before OMS | 0 | 5/8 (62.5%) |
| Within 10 yrs before OMS | 0 | 3/8 (37.5%) |
| Within 2 yrs before OMS | 2/2 (100%) | 0 |
| Constipation; n | 14 | 15 |
| Coincidentally or after OMS (n;%) | 5 (35.7%) | 8 (53.3%) |
| Before OMS (n;%) | 9 (64.3%) | 7 (46.7%) |
| More than 10 yrs before OMS | 8/9 (88.9%) | 7/7 (100%) |
| Within 10 yrs before OMS | 1/9 (11.1%) | 0 |
| Within 2 yrs before OMS | 0 | 0 |
| Urinary dysfunction; n | 17 | 15 |
| Coincidentally or after OMS (n;%) | 12 (70.6%) | 12 (80%) |
| Before OMS (n;%) | 5 (29.4%) | 3 (20%) |
| More than 10 yrs before OMS | 0 | 0 |
| Within 10 yrs before OMS | 1/5 (20%) | 1/3 (33.3%) |
| Within 2 yrs before OMS | 4/5 (80%) | 2/3 (66.6%) |
| RBD symptoms; n | 7 | 14 |
| Coincidentally or after OMS (n;%) | 5 (71.4%) | 12 (85.7%) |
| Before OMS (n;%) | 2 (28.6%) | 2 (14.3%) |
| More than 10 yrs before OMS | 0 | 0 |
| Within 10 yrs before OMS | ½ (50%) | 0/2 (0.0%) |
| Within 2 yrs before OMS | ½ (50%) | 2/2 (100%) |
| Insomnia; n | 19 | 22 |
| Coincidentally or after OMS (n;%) | 16 (84.2%) | 14 (63.6%) |
| Before OMS (n;%) | 3 (15.8%) | 8 (36.4%) |
| More than 10 yrs before OMS | 2/3 (66.6%) | 6/8 (75%) |
| Within 10 yrs before OMS | 0 | 0 |
| Within 2 yrs before OMS | 1/3 (33.3%) | 2/8 (25%) |
| EDS; n | 6 | 13 |
| Coincidentally or after OMS (n;%) | 3 (50%) | 12 (92.3%) |
| Before OMS (n;%) | 3 (50%) | 1 (7.7%) |
| More than 10 yrs before OMS | 2/3 (66.6%) | 1/1 (100%) |
| Within 10 yrs before OMS | 1/3 (33.3%) | 0 |
| Within 2 yrs before OMS | 0 | 0 |
LRRK2 G2019S PD: LRRK2 G2019S related Parkinson’s disease; IPD: Idiopathic Parkinson’s disease, OMS: onset of motor symptoms, RBD: REM sleep behavior disorder, EDS: excessive daytime sleepiness.