. 2014 Oct 17;9(10):e109725. doi: 10.1371/journal.pone.0109725

Table 1. Patient demographics.

	Control	Moderate	Severe	P value
Sex, M/F	5/5	9/3	7/5	0.474
Age, yr	65.5 (60.3, 77.5)	61.5 (57.5, 72)	51 (46.8, 62) ^a,b	0.01
Height, in	66.5 (62, 72)	68.5 (66.3, 70)	66.5 (64.3, 69)	0.631
Weight, lb	175 (145, 200)	195 (155, 220)	155 (125, 180)	0.162
Cigarette, pack-yrs	29 (18.8, 55)	45 (33, 59)	41 (32, 81.5)	0.380
SF12 score, physical	37.1 (30.5, 56.4)	30.7 (25.3, 39.3)	26.8 (24.9, 30.3) ^a	0.01
St. George's score	20.2 (4.5, 49.6)	47.2 (31.4, 67.6)	53.5 (49.9, 63) ^a	0.015
% predicted, FEV1 pre	93.5 (85.5, 97.5)	61.5 (56.5, 69.5) ^a	20 (17.5, 23.5) ^a,b	<0.0001
% predicted, FEV6 pre	101 (90.3, 115.3)	79.5 (66.3, 89) ^a	38.5 (34.3, 48.8) ^a,b	<0.0001
% predicted, FVC pre	100 (89.5, 110.8)	82 (64.3, 91) ^a	51 (42.3, 62) ^a,b	<0.0001
% predicted, PEFR pre	98.5 (89.5, 112.3)	76.5 (67.3, 81.8)	30.5 (26.3, 32.8) ^a,b	<0.0001
Pre-FEV1/FVC ratio	0.7 (0.68, 0.8)	0.6 (0.5, 0.7) ^a	0.3 (0.23, 0.38) ^a,b	<0.0001
% predicted, FEV1 post	97.5 (89, 106)	67 (65, 76) ^a	19.5 (16.5, 22.5) ^a,b	<0.0001
% predicted, FEV6 post	108.5 (103, 120)	88 (80, 90) ^a	42 (39, 47) ^a,b	0.002
% predicted, FVC post	107.5 (102, 117)	91 (87, 96) ^a	50 (38, 62) ^a,b	0.002
% predicted, PEFR post	108 (94.5, 124.8)	88 (69, 90) ^a	28 (22.3, 48.8) ^a,b	<0.0001
Post-FEV1/FVC ratio	0.7 (0.6, 0.73)	0.6 (0.5, 0.6) ^a	0.35 (0.23, 0.4) ^a,b	0.003
Perdlco	87 (64.3, 111.5)	58 (31, 75)	45 (25, 55.5) ^a	0.012

Values are medians (25^th, 75^th percentile). Perdlco, severity classification of DLCO abnormality (continuous). Severity was grouped using Gold standard according to REV1pd1a (see Methods): Controls ≥80%; Moderate ≥50 and <80%; Severe <50%. Statistical analysis was performed using Mann-Whitney U test and Kruskal-Wallis ANOVA. P value <0.05 was considered significant. ^aP<0.05 compared with Control group; ^bP<0.05 versus moderate stage.