Table 2. Correlation of channel proteins with lung function.

	Spearman coefficient	P value	Correlation strength	P value
ENaC
Protein/β actin ( total )
γ ENaC vs fev1prd1	−0.690	0.003	−1.5	0.016
Protein/Pro-SPC ( ATII )
α ENaC vs fev1pd1a	−0.705	0.003	−1.3	0.007
vs pefrprd1	−0.833	0.01	−1.1	0.004
Protein/AQP5 ( ATI )
α ENaC vs fev1pd1a	−0.757	<0.0001	−68.5	0.003
β ENaC vs fev1pd1a	−0.773	<0.0001	−102.8	<0.0001
vs perdlco	−0.782	0.008	−109.8	0.005
CFTR
Protein/β actin ( total )
vs fev1prd2	0.881	0.004	75.5	0.005
Protein/Pro-SPC ( ATII )
vs sf12pcs	0.867	0.003	2.9	0.034
vs fev1pd1a	0.778	0.003	9.5	<0.001
vs fev6prd1	0.9	<0.0001	7.7	0.012
vs fvcprd1	0.902	<0.0001	8.1	0.002
vs fev1prd2	0.929	0.003	10.6	0.006
vs fvcprd2	0.929	0.003	7.2	0.027
Protein/AQP5 ( ATI )
vs fev1prd2	0.929	<0.0001	927	0.001
vs fev6prd2	0.893	0.007	772	0.006
vs fvcprd2	0.952	<0.0001	722	<0.001
AQP5 (ATI)
Protein/β actin ( total )
vs fev1pd1a	0.669	0.005	47.9	0.01
vs perdlco	0.903	<0.0001	72.2	<0.001
SOD3
Protein/β actin ( total )
vs perdlco	0.879	<0.0001	45.7	<0.001

Spearman correlation coefficient constants and P values were computed. Corresponding correlation strength was computed by fitting data with a linear regression function. fev1pd1a, FEV1 pre-bronchodilator % predicted (continuous); pefrprd1, PEFR post-bronchodilator % predicted; perdlco, severity classification of DLCO abnormality (continuous); fev1prd2, FEV1 post-bronchodilator % predicted (continuous); sf12pcs, SF12 physical component score; fev6prd1, FEV6 pre-bronchodilator % predicted; fev1prd2, FEV1 post-bronchodilator % predicted (continuous); fvcprd2, FVC post-bronchodilator % predicted. Additional expanded abbreviations can be found in Table 1. Spearman coefficients (between −1 and +1) were calculated using Origin Pro 8.5.