Figure 5. Comparison of MK-2206 binding and interacting residues of all three isoforms of AKT.

Only one residue Asn-53 was shared among interacting residues of AKT1 and AKT2, and shown as encircled in green. Three position-equivalent-residues (residues of different isoforms falling at same column position in the isoform alignment) were shared among interacting residues of AKT2 and AKT3, and shown as encircled in red.