Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Oct 17;9(10):e109705. doi: 10.1371/journal.pone.0109705

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Rehan et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

Panels A–B: Schematic structure of MK-2206 and its analog are shown. The only difference between the compounds is change in R₂ group, shown in red on black compound-scaffold. Panel C–D: The binding of MK-2206 and its selected analog are displayed. The residues involved in hydrophobic interactions are shown as red arcs. The interacting residues which are common for both the ligands are encircled.