Table 6. The AKT1 residues interacting with MK-2206 analog are listed with the number of non-bonding contacts and the loss in Accessible Surface Area (ASA).
Interacting residues | No. of hydrophobic contacts | ΔASA (Å2) |
Asn-53 | 6 | 51.382 |
Asn-54 | 2 | 13.839 |
Gln-79 | 9 | 37.294 |
Trp-80 | 7 | 66.431 |
Leu-264 | 1 | 14.218 |
Val-270 | 5 | 37.863 |
Val-271 | 2 | 6.1110 |
Tyr-272 | 4 | 36.185 |
Arg-273 | 1 | 31.286 |
Asp-292 | 3 | 15.677 |
The ranking of residues on the basis of loss in solvent accessibility is indicated by superscripts with the value of ΔASA.