Table 4. Pharmacokinetic parameters of SP-141 in CD-1 mice after administrations of single dose of 40 mg/kg via intraperitoneal (IP) and intravenous (IV) routes.
Routes | T1/2 (h) | Tmax (mins) | Cmax (ng/mL) | AUC0–t (h ng/mL) | AUC0-∞ (h ng/mL) |
---|---|---|---|---|---|
IP | 1.78 | 10 | 4422 | 12650 | 13170 |
IV | 0.98 | Not applicable | 5531 | 8340 | 8541 |